Drug interactions
Epinephrine racemic + Hydrochlorothiazide-olmesartan
Severity: Minor
Epinephrine racemic and Hydrochlorothiazide-olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine given by inhalation or systemically can lower serum potassium via beta-2 receptor stimulation, adding to thiazide-induced potassium loss. Systemic absorption from inhalation is usually modest, so the effect is typically small, though it matters in patients with cardiac disease.
What this interaction means in plain words
Epinephrine racemic and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Beta-2 mediated intracellular potassium shift added to thiazide-induced renal potassium wasting.
What to do
Check serum potassium in patients with cardiac disease or repeated high dosing of epinephrine. Correct hypokalemia if present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Epinephrine racemic with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as minor. Epinephrine racemic and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Racemic epinephrine given by inhalation or systemically can lower serum potassium via beta-2 receptor stimulation, adding to thiazide-induced potassium loss. Systemic absorption from inhalation is usually modest, so the effect is typically small, though it matters in patients with cardiac disease.
How serious is the interaction between Epinephrine racemic and Hydrochlorothiazide-olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in patients with cardiac disease or repeated high dosing of epinephrine. Correct hypokalemia if present.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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