Drug interactions
Epinephrine racemic + Levosalbutamol
Severity: Moderate
Epinephrine racemic and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine is a potent adrenergic agonist, and combining it with levosalbutamol increases beta-adrenergic effects. This may cause tachycardia, arrhythmias, hypertension, tremor and hypokalemia.
What this interaction means in plain words
Epinephrine racemic and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation of cardiac and metabolic beta receptors, including beta-2 mediated potassium shift.
What to do
Monitor heart rate, blood pressure, ECG and serum potassium if both are given close together. Avoid routine scheduled duplication of beta-agonist therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Frequently asked questions
Can I take Epinephrine racemic with Levosalbutamol?
MediHelp rates the interaction as moderate. Epinephrine racemic and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine is a potent adrenergic agonist, and combining it with levosalbutamol increases beta-adrenergic effects. This may cause tachycardia, arrhythmias, hypertension, tremor and hypokalemia.
How serious is the interaction between Epinephrine racemic and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure, ECG and serum potassium if both are given close together. Avoid routine scheduled duplication of beta-agonist therapy.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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