Drug interactions
Epinephrine racemic + Olanzapine
Severity: Minor
Epinephrine racemic and Olanzapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine's alpha-1 blockade may reduce the pressor effect of epinephrine, and unopposed beta-mediated vasodilation could lower blood pressure further. Racemic epinephrine is usually given by inhalation, so the effect is limited.
What this interaction means in plain words
Epinephrine racemic and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Alpha-1 adrenergic blockade by olanzapine opposing epinephrine's vasoconstriction.
What to do
No routine change is needed. Monitor blood pressure if systemic or high-dose epinephrine is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Epinephrine racemic with Olanzapine?
MediHelp rates the interaction as minor. Epinephrine racemic and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olanzapine's alpha-1 blockade may reduce the pressor effect of epinephrine, and unopposed beta-mediated vasodilation could lower blood pressure further. Racemic epinephrine is usually given by inhalation, so the effect is limited.
How serious is the interaction between Epinephrine racemic and Olanzapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor blood pressure if systemic or high-dose epinephrine is required.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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