Drug interactions
Ergoloid mesylates + Frovatriptan
Severity: Contraindicated
Ergoloid mesylates and Frovatriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergoloid mesylates are ergot derivatives, and combining them with a triptan may add to vasoconstriction. The risk of vasospastic ischemia is of concern, although ergoloids have weaker vasoconstrictor action than other ergots.
What this interaction means in plain words
Ergoloid mesylates and Frovatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive vasoconstrictive effects of a 5-HT1B/1D agonist and an ergot alkaloid.
What to do
Avoid use within 24 hours of each other. Review whether ergoloid therapy is still necessary.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ergoloid mesylates and Frovatriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
- Frovatriptan + Methylergonovine Contraindicated
Frequently asked questions
Can I take Ergoloid mesylates with Frovatriptan?
MediHelp rates the interaction as contraindicated. Ergoloid mesylates and Frovatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ergoloid mesylates are ergot derivatives, and combining them with a triptan may add to vasoconstriction. The risk of vasospastic ischemia is of concern, although ergoloids have weaker vasoconstrictor action than other ergots.
How serious is the interaction between Ergoloid mesylates and Frovatriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use within 24 hours of each other. Review whether ergoloid therapy is still necessary.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
