Drug interactions
Ergoloid mesylates + Phenylephrine
Severity: Minor
Ergoloid mesylates and Phenylephrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergoloid mesylates has only weak vasoconstrictor activity compared with classic ergot alkaloids, so a significant additive pressor effect with phenylephrine is not well established. The legacy contraindication appears to be extrapolated from other ergot derivatives.
What this interaction means in plain words
Ergoloid mesylates and Phenylephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive vasoconstriction; ergoloid has dopaminergic and serotonergic activity with little vasospastic effect.
What to do
No specific action is needed beyond monitoring blood pressure if systemic phenylephrine is given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Frequently asked questions
Can I take Ergoloid mesylates with Phenylephrine?
MediHelp rates the interaction as minor. Ergoloid mesylates and Phenylephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ergoloid mesylates has only weak vasoconstrictor activity compared with classic ergot alkaloids, so a significant additive pressor effect with phenylephrine is not well established. The legacy contraindication appears to be extrapolated from other ergot derivatives.
How serious is the interaction between Ergoloid mesylates and Phenylephrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond monitoring blood pressure if systemic phenylephrine is given.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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