Drug interactions
Ergoloid mesylates + Pimozide
Severity: Moderate
Ergoloid mesylates and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergoloid mesylates has dopaminergic and serotonergic activity, and combined use with an antipsychotic could in theory alter dopamine blockade and raise the risk of neuroleptic malignant syndrome or serotonin toxicity. Documented clinical cases are lacking.
What this interaction means in plain words
Ergoloid mesylates and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical pharmacodynamic interaction at dopamine and serotonin receptors; the mechanism is not firmly established.
What to do
Monitor for hyperthermia, rigidity, autonomic instability and mental status changes after starting or changing doses. Stop one agent if features of NMS or serotonin toxicity develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ergoloid mesylates and Pimozide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Ergoloid mesylates with Pimozide?
MediHelp rates the interaction as moderate. Ergoloid mesylates and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergoloid mesylates has dopaminergic and serotonergic activity, and combined use with an antipsychotic could in theory alter dopamine blockade and raise the risk of neuroleptic malignant syndrome or serotonin toxicity. Documented clinical cases are lacking.
How serious is the interaction between Ergoloid mesylates and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, autonomic instability and mental status changes after starting or changing doses. Stop one agent if features of NMS or serotonin toxicity develop.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
