Drug interactions
Erythromycin base + Indapamide
Severity: Major
Erythromycin base and Indapamide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin prolongs the QT interval and can cause torsades de pointes. Indapamide-induced hypokalemia or hypomagnesemia increases that risk.
What this interaction means in plain words
Erythromycin base and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation with diuretic-induced electrolyte depletion.
What to do
Check potassium and magnesium and correct deficits, and obtain an ECG in patients with other risk factors. Consider azithromycin or a non-macrolide alternative.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Indapamide
Frequently asked questions
Can I take Erythromycin base with Indapamide?
MediHelp rates the interaction as major. Erythromycin base and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin prolongs the QT interval and can cause torsades de pointes. Indapamide-induced hypokalemia or hypomagnesemia increases that risk.
How serious is the interaction between Erythromycin base and Indapamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and correct deficits, and obtain an ECG in patients with other risk factors. Consider azithromycin or a non-macrolide alternative.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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