Drug interactions
Erythromycin base + Octreotide
Severity: Moderate
Erythromycin base and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin prolongs the QT interval and has been linked to torsades de pointes, and octreotide may add to this through bradycardia and repolarization effects. Risk is higher with other risk factors such as electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Erythromycin base and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation.
What to do
Consider a non-macrolide alternative if the patient has other QT risk factors; otherwise obtain an ECG and correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Frequently asked questions
Can I take Erythromycin base with Octreotide?
MediHelp rates the interaction as moderate. Erythromycin base and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin prolongs the QT interval and has been linked to torsades de pointes, and octreotide may add to this through bradycardia and repolarization effects. Risk is higher with other risk factors such as electrolyte disturbance or cardiac disease.
How serious is the interaction between Erythromycin base and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-macrolide alternative if the patient has other QT risk factors; otherwise obtain an ECG and correct potassium and magnesium.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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