Drug interactions
Erythromycin base + Rabeprazole
Severity: Minor
Erythromycin base and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4, a minor pathway for rabeprazole, so exposure may rise slightly. The combination is commonly used in H. pylori regimens without significant problems.
What this interaction means in plain words
Erythromycin base and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin inhibits CYP3A4, a minor route of rabeprazole metabolism.
What to do
No dose adjustment is needed; monitor for adverse effects of either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Erythromycin base with Rabeprazole?
MediHelp rates the interaction as minor. Erythromycin base and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4, a minor pathway for rabeprazole, so exposure may rise slightly. The combination is commonly used in H. pylori regimens without significant problems.
How serious is the interaction between Erythromycin base and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for adverse effects of either drug.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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