Drug interactions
Erythromycin ethylsuccinate + Etoposide
Severity: Moderate
Erythromycin ethylsuccinate and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and P-glycoprotein and may increase etoposide concentrations. This may heighten myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Erythromycin ethylsuccinate and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces etoposide metabolism and efflux.
What to do
Monitor blood counts and for etoposide toxicity during co-therapy. Consider a non-inhibiting antibiotic such as an alternative class if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Etoposide?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and P-glycoprotein and may increase etoposide concentrations. This may heighten myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Erythromycin ethylsuccinate and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for etoposide toxicity during co-therapy. Consider a non-inhibiting antibiotic such as an alternative class if appropriate.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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