Drug interactions
Erythromycin ethylsuccinate + Glimepiride-pioglitazone
Severity: Minor
Erythromycin ethylsuccinate and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and may modestly raise exposure to pioglitazone, though CYP2C8 is its main metabolic pathway. The clinical effect is likely small.
What this interaction means in plain words
Erythromycin ethylsuccinate and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin inhibits CYP3A4, which contributes to pioglitazone metabolism.
What to do
No dose change is usually required. Monitor blood glucose and for edema during the antibiotic course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Erythromycin ethylsuccinate and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4 and may modestly raise exposure to pioglitazone, though CYP2C8 is its main metabolic pathway. The clinical effect is likely small.
How serious is the interaction between Erythromycin ethylsuccinate and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor blood glucose and for edema during the antibiotic course.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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