Drug interactions
Erythromycin ethylsuccinate + Tofacitinib
Severity: Moderate
Erythromycin ethylsuccinate and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and can raise tofacitinib exposure, increasing the risk of dose-related adverse effects such as infection and cytopenias. The effect is typically modest.
What this interaction means in plain words
Erythromycin ethylsuccinate and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated tofacitinib metabolism by erythromycin.
What to do
Monitor for tofacitinib adverse effects such as infection and cytopenias; consider reducing the tofacitinib dose if a CYP2C19 inhibitor is also taken.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Tofacitinib?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and can raise tofacitinib exposure, increasing the risk of dose-related adverse effects such as infection and cytopenias. The effect is typically modest.
How serious is the interaction between Erythromycin ethylsuccinate and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tofacitinib adverse effects such as infection and cytopenias; consider reducing the tofacitinib dose if a CYP2C19 inhibitor is also taken.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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