Drug interactions
Erythromycin ethylsuccinate + Topiramate
Severity: Minor
Erythromycin ethylsuccinate and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate is a weak CYP3A4 inducer and could slightly lower erythromycin exposure. This is unlikely to be clinically meaningful in a typical antibiotic course.
What this interaction means in plain words
Erythromycin ethylsuccinate and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak induction of CYP3A4 by topiramate may modestly increase erythromycin metabolism.
What to do
No routine adjustment is required. Assess clinical response if infection fails to improve.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Topiramate
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Topiramate?
MediHelp rates the interaction as minor. Erythromycin ethylsuccinate and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topiramate is a weak CYP3A4 inducer and could slightly lower erythromycin exposure. This is unlikely to be clinically meaningful in a typical antibiotic course.
How serious is the interaction between Erythromycin ethylsuccinate and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Assess clinical response if infection fails to improve.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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