Drug interactions
Erythromycin stearate + Griseofulvin
Severity: Minor
Erythromycin stearate and Griseofulvin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a weak inducer of hepatic enzymes and could in theory lower erythromycin exposure. The clinical effect is poorly documented, and a contraindication is not supported by labeling or evidence.
What this interaction means in plain words
Erythromycin stearate and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak induction of CYP3A4 by griseofulvin, which may modestly increase erythromycin metabolism.
What to do
No routine adjustment is needed; watch for reduced antibacterial response if erythromycin is given for a prolonged course with griseofulvin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Erythromycin stearate with Griseofulvin?
MediHelp rates the interaction as minor. Erythromycin stearate and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a weak inducer of hepatic enzymes and could in theory lower erythromycin exposure. The clinical effect is poorly documented, and a contraindication is not supported by labeling or evidence.
How serious is the interaction between Erythromycin stearate and Griseofulvin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for reduced antibacterial response if erythromycin is given for a prolonged course with griseofulvin.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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