Drug interactions
Erythromycin stearate + Rabeprazole
Severity: Minor
Erythromycin stearate and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4, which plays a minor role in rabeprazole clearance, so rabeprazole exposure could rise slightly. Rabeprazole is mainly cleared by non-enzymatic reduction, so the clinical effect is expected to be negligible.
What this interaction means in plain words
Erythromycin stearate and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by erythromycin may slightly reduce the minor CYP-mediated metabolism of rabeprazole.
What to do
No dose adjustment is needed; the combination is commonly used in Helicobacter pylori regimens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Erythromycin stearate with Rabeprazole?
MediHelp rates the interaction as minor. Erythromycin stearate and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4, which plays a minor role in rabeprazole clearance, so rabeprazole exposure could rise slightly. Rabeprazole is mainly cleared by non-enzymatic reduction, so the clinical effect is expected to be negligible.
How serious is the interaction between Erythromycin stearate and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; the combination is commonly used in Helicobacter pylori regimens.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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