Drug interactions
Escitalopram + Fenoprofen
Severity: Moderate
Escitalopram and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs reduce platelet serotonin and, combined with NSAIDs, raise the risk of upper gastrointestinal bleeding above either agent alone. The risk is higher in older patients and those with ulcer history.
What this interaction means in plain words
Escitalopram and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Fenoprofen belongs to Musculoskeletal.
Why it happens
Additive impairment of platelet function (SSRI serotonin depletion plus NSAID COX inhibition) and NSAID gastric mucosal injury.
What to do
Consider gastroprotection with a proton pump inhibitor in patients at GI risk and use the lowest effective NSAID dose. Counsel patients to report black stools or vomiting blood.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Fenoprofen?
MediHelp rates the interaction as moderate. Escitalopram and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs reduce platelet serotonin and, combined with NSAIDs, raise the risk of upper gastrointestinal bleeding above either agent alone. The risk is higher in older patients and those with ulcer history.
How serious is the interaction between Escitalopram and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor in patients at GI risk and use the lowest effective NSAID dose. Counsel patients to report black stools or vomiting blood.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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