Drug interactions
Escitalopram + Fosamprenavir
Severity: Moderate
Escitalopram and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (as amprenavir, boosted or not) inhibits CYP3A4, which contributes to escitalopram metabolism, so escitalopram levels may rise modestly. This could increase serotonergic effects and QT prolongation, although CYP2C19 is the major pathway.
What this interaction means in plain words
Escitalopram and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by amprenavir reducing escitalopram clearance.
What to do
Monitor for escitalopram adverse effects and adjust the dose if needed. Obtain an ECG if other QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Fosamprenavir?
MediHelp rates the interaction as moderate. Escitalopram and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir (as amprenavir, boosted or not) inhibits CYP3A4, which contributes to escitalopram metabolism, so escitalopram levels may rise modestly. This could increase serotonergic effects and QT prolongation, although CYP2C19 is the major pathway.
How serious is the interaction between Escitalopram and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for escitalopram adverse effects and adjust the dose if needed. Obtain an ECG if other QT risk factors exist.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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