Drug interactions
Escitalopram + Lamotrigine
Severity: Minor
Escitalopram and Lamotrigine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs are commonly combined for mood disorders with generally good tolerability. Additive drowsiness or dizziness can occur, and rare serotonergic adverse effects have been described with lamotrigine and SSRIs.
What this interaction means in plain words
Escitalopram and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Escitalopram belongs to Central Nervous System; Lamotrigine belongs to Central Nervous System.
Why it happens
Mechanism is not firmly established; possible additive CNS effects, with no major pharmacokinetic interaction.
What to do
No dose change is routinely needed; monitor for sedation, dizziness and any new neuropsychiatric symptoms after starting or adjusting either agent.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Escitalopram and Lamotrigine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Lamotrigine
Frequently asked questions
Can I take Escitalopram with Lamotrigine?
MediHelp rates the interaction as minor. Escitalopram and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The two drugs are commonly combined for mood disorders with generally good tolerability. Additive drowsiness or dizziness can occur, and rare serotonergic adverse effects have been described with lamotrigine and SSRIs.
How serious is the interaction between Escitalopram and Lamotrigine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for sedation, dizziness and any new neuropsychiatric symptoms after starting or adjusting either agent.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
