Drug interactions
Escitalopram + Metoclopramide intranasal
Severity: Moderate
Escitalopram and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide has been associated with extrapyramidal effects and neuroleptic malignant syndrome, and serotonin syndrome has been reported with SSRIs. Combining it with an SSRI may increase the risk of these CNS reactions.
What this interaction means in plain words
Escitalopram and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and dopamine antagonist effects; the exact mechanism is not fully established.
What to do
Monitor for tremor, rigidity, agitation and other serotonin syndrome or extrapyramidal signs. Consider an alternative antiemetic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Escitalopram and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide has been associated with extrapyramidal effects and neuroleptic malignant syndrome, and serotonin syndrome has been reported with SSRIs. Combining it with an SSRI may increase the risk of these CNS reactions.
How serious is the interaction between Escitalopram and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, rigidity, agitation and other serotonin syndrome or extrapyramidal signs. Consider an alternative antiemetic if symptoms develop.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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