Drug interactions
Escitalopram + Romidepsin
Severity: Moderate
Escitalopram and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and romidepsin has been linked to ECG changes. Together they may increase the risk of torsades de pointes, especially with low potassium or magnesium.
What this interaction means in plain words
Escitalopram and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Obtain a baseline ECG and monitor it during treatment. Correct potassium and magnesium before each romidepsin dose and consider an alternative antidepressant in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Romidepsin?
MediHelp rates the interaction as moderate. Escitalopram and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval and romidepsin has been linked to ECG changes. Together they may increase the risk of torsades de pointes, especially with low potassium or magnesium.
How serious is the interaction between Escitalopram and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during treatment. Correct potassium and magnesium before each romidepsin dose and consider an alternative antidepressant in high-risk patients.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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