Drug interactions
Escitalopram + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Escitalopram and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta-agonist that can affect cardiac rhythm and QT interval, particularly at high exposure. Escitalopram prolongs the QT interval in a dose-related fashion. Systemic exposure from inhalation is low, so the clinical risk is modest but may matter in patients with cardiac disease.
What this interaction means in plain words
Escitalopram and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and possible beta-agonist-related hypokalemia and arrhythmia potentiation.
What to do
Use at recommended doses and monitor for palpitations or arrhythmia, especially in patients with cardiac disease. Consider an ECG and electrolyte check in higher-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Escitalopram and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a long-acting beta-agonist that can affect cardiac rhythm and QT interval, particularly at high exposure. Escitalopram prolongs the QT interval in a dose-related fashion. Systemic exposure from inhalation is low, so the clinical risk is modest but may matter in patients with cardiac disease.
How serious is the interaction between Escitalopram and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use at recommended doses and monitor for palpitations or arrhythmia, especially in patients with cardiac disease. Consider an ECG and electrolyte check in higher-risk patients.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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