Drug interactions
Escitalopram + Vorapaxar
Severity: Moderate
Escitalopram and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is a platelet inhibitor that increases bleeding risk, and SSRIs impair platelet function. Used together they may further raise the risk of bleeding, including gastrointestinal and intracranial hemorrhage.
What this interaction means in plain words
Escitalopram and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet function: PAR-1 antagonism by vorapaxar and platelet serotonin depletion by escitalopram.
What to do
Monitor for signs of bleeding and consider gastroprotection in patients at higher GI risk. Reassess the need for the combination if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Vorapaxar?
MediHelp rates the interaction as moderate. Escitalopram and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorapaxar is a platelet inhibitor that increases bleeding risk, and SSRIs impair platelet function. Used together they may further raise the risk of bleeding, including gastrointestinal and intracranial hemorrhage.
How serious is the interaction between Escitalopram and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider gastroprotection in patients at higher GI risk. Reassess the need for the combination if bleeding occurs.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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