Drug interactions
Esketamine + Estazolam
Severity: Moderate
Esketamine and Estazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estazolam is a benzodiazepine hypnotic, and together with esketamine it can produce deeper sedation and slower breathing than either drug alone. Impaired coordination and next-day impairment are also more likely.
What this interaction means in plain words
Esketamine and Estazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation by the benzodiazepine and NMDA receptor antagonism by esketamine.
What to do
Monitor sedation and respiratory status through the post-dose observation period, and consider holding the benzodiazepine dose on treatment days. Counsel the patient on avoiding driving and hazardous activity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Estazolam?
MediHelp rates the interaction as moderate. Esketamine and Estazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estazolam is a benzodiazepine hypnotic, and together with esketamine it can produce deeper sedation and slower breathing than either drug alone. Impaired coordination and next-day impairment are also more likely.
How serious is the interaction between Esketamine and Estazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status through the post-dose observation period, and consider holding the benzodiazepine dose on treatment days. Counsel the patient on avoiding driving and hazardous activity.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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