Drug interactions
Esketamine + Ethotoin
Severity: Moderate
Esketamine and Ethotoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethotoin, a hydantoin anticonvulsant, can cause drowsiness and ataxia, which may add to esketamine sedation. Combined use may impair alertness and coordination.
What this interaction means in plain words
Esketamine and Ethotoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and ataxia during and after esketamine sessions. Counsel patients to avoid driving or machinery until the next day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Ethotoin?
MediHelp rates the interaction as moderate. Esketamine and Ethotoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethotoin, a hydantoin anticonvulsant, can cause drowsiness and ataxia, which may add to esketamine sedation. Combined use may impair alertness and coordination.
How serious is the interaction between Esketamine and Ethotoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and ataxia during and after esketamine sessions. Counsel patients to avoid driving or machinery until the next day.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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