Drug interactions
Esketamine + Lamotrigine
Severity: Minor
Esketamine and Lamotrigine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lamotrigine can cause drowsiness and dizziness, which may add to esketamine's sedation. Lamotrigine also modulates glutamate release and may blunt some dissociative effects of NMDA antagonists.
What this interaction means in plain words
Esketamine and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esketamine belongs to Central Nervous System; Lamotrigine belongs to Central Nervous System.
Why it happens
Additive CNS effects; lamotrigine inhibits glutamate release, which may reduce dissociative effects.
What to do
No dose change is usually required; monitor for sedation after dosing and counsel on driving restrictions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Other interactions of Lamotrigine
Frequently asked questions
Can I take Esketamine with Lamotrigine?
MediHelp rates the interaction as minor. Esketamine and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lamotrigine can cause drowsiness and dizziness, which may add to esketamine's sedation. Lamotrigine also modulates glutamate release and may blunt some dissociative effects of NMDA antagonists.
How serious is the interaction between Esketamine and Lamotrigine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor for sedation after dosing and counsel on driving restrictions.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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