Drug interactions
Esketamine + Metoclopramide intranasal
Severity: Minor
Esketamine and Metoclopramide intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on the CNS, and metoclopramide can cause extrapyramidal reactions and drowsiness. Esketamine may add dizziness and sedation, but the interaction is not well characterized.
What this interaction means in plain words
Esketamine and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS effects; no specific mechanism is established.
What to do
Monitor for sedation and movement disorders. Counsel the patient about driving restrictions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Metoclopramide intranasal?
MediHelp rates the interaction as minor. Esketamine and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs act on the CNS, and metoclopramide can cause extrapyramidal reactions and drowsiness. Esketamine may add dizziness and sedation, but the interaction is not well characterized.
How serious is the interaction between Esketamine and Metoclopramide intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and movement disorders. Counsel the patient about driving restrictions.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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