Drug interactions
Esketamine + Nicotine gum
Severity: Moderate
Esketamine and Nicotine gum: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine can raise blood pressure and heart rate shortly after dosing, and nicotine has its own sympathomimetic cardiovascular effects. Together they may produce a larger or more prolonged rise in blood pressure and pulse.
What this interaction means in plain words
Esketamine and Nicotine gum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic pressor and chronotropic effects of esketamine and nicotine.
What to do
Measure blood pressure before esketamine dosing and about 40 minutes afterward, and continue monitoring until it stabilizes. Consider delaying nicotine use around the session in patients with elevated baseline pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Nicotine gum?
MediHelp rates the interaction as moderate. Esketamine and Nicotine gum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine can raise blood pressure and heart rate shortly after dosing, and nicotine has its own sympathomimetic cardiovascular effects. Together they may produce a larger or more prolonged rise in blood pressure and pulse.
How serious is the interaction between Esketamine and Nicotine gum?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure blood pressure before esketamine dosing and about 40 minutes afterward, and continue monitoring until it stabilizes. Consider delaying nicotine use around the session in patients with elevated baseline pressure.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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