Drug interactions
Esketamine + Nicotine inhaled
Severity: Moderate
Esketamine and Nicotine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine transiently elevates blood pressure and heart rate, and inhaled nicotine adds sympathetic stimulation. The combined effect may cause greater hemodynamic elevation than either agent alone.
What this interaction means in plain words
Esketamine and Nicotine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic pressor and chronotropic effects of esketamine and nicotine.
What to do
Check blood pressure before and after esketamine dosing, and reassess if it is markedly elevated. Advise patients to avoid nicotine inhalation immediately before and during the post-dose observation period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Nicotine inhaled?
MediHelp rates the interaction as moderate. Esketamine and Nicotine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine transiently elevates blood pressure and heart rate, and inhaled nicotine adds sympathetic stimulation. The combined effect may cause greater hemodynamic elevation than either agent alone.
How serious is the interaction between Esketamine and Nicotine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure before and after esketamine dosing, and reassess if it is markedly elevated. Advise patients to avoid nicotine inhalation immediately before and during the post-dose observation period.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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