Drug interactions
Esketamine + Olanzapine
Severity: Moderate
Esketamine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is a sedating atypical antipsychotic that can cause somnolence and orthostatic hypotension. With esketamine it may add to sedation and impair alertness after dosing.
What this interaction means in plain words
Esketamine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from antipsychotic receptor blockade and esketamine sedation.
What to do
Monitor sedation and blood pressure during post-dose observation. Review the olanzapine dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Olanzapine
Frequently asked questions
Can I take Esketamine with Olanzapine?
MediHelp rates the interaction as moderate. Esketamine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine is a sedating atypical antipsychotic that can cause somnolence and orthostatic hypotension. With esketamine it may add to sedation and impair alertness after dosing.
How serious is the interaction between Esketamine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during post-dose observation. Review the olanzapine dose if excessive sedation occurs.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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