Drug interactions
Esketamine + Olopatadine intranasal
Severity: Minor
Esketamine and Olopatadine intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and olopatadine nasal spray can cause somnolence. Together they may increase drowsiness and impair psychomotor performance.
What this interaction means in plain words
Esketamine and Olopatadine intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression.
What to do
Monitor for excessive sedation and advise against driving after esketamine dosing. Space the nasal sprays as directed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Olopatadine intranasal?
MediHelp rates the interaction as minor. Esketamine and Olopatadine intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Esketamine causes sedation and dissociation, and olopatadine nasal spray can cause somnolence. Together they may increase drowsiness and impair psychomotor performance.
How serious is the interaction between Esketamine and Olopatadine intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and advise against driving after esketamine dosing. Space the nasal sprays as directed.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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