Drug interactions
Esketamine + Orphenadrine
Severity: Moderate
Esketamine and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is a sedating anticholinergic muscle relaxant, and it may add to esketamine's drowsiness, dizziness and cognitive impairment. Anticholinergic effects such as confusion may be more marked in older adults.
What this interaction means in plain words
Esketamine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and central anticholinergic effects combined with NMDA antagonism.
What to do
Monitor sedation and mental status after dosing and avoid scheduling orphenadrine around esketamine sessions. Use a lower dose in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Orphenadrine?
MediHelp rates the interaction as moderate. Esketamine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is a sedating anticholinergic muscle relaxant, and it may add to esketamine's drowsiness, dizziness and cognitive impairment. Anticholinergic effects such as confusion may be more marked in older adults.
How serious is the interaction between Esketamine and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and mental status after dosing and avoid scheduling orphenadrine around esketamine sessions. Use a lower dose in older patients.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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