Drug interactions
Esketamine + Phendimetrazine
Severity: Moderate
Esketamine and Phendimetrazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic that can raise blood pressure and heart rate, as can esketamine. Combined use may cause additive hypertension and tachycardia.
What this interaction means in plain words
Esketamine and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic effects increasing blood pressure and heart rate.
What to do
Check blood pressure before esketamine dosing and monitor afterward until stable. Avoid starting esketamine if baseline pressure is uncontrolled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Phendimetrazine?
MediHelp rates the interaction as moderate. Esketamine and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic that can raise blood pressure and heart rate, as can esketamine. Combined use may cause additive hypertension and tachycardia.
How serious is the interaction between Esketamine and Phendimetrazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure before esketamine dosing and monitor afterward until stable. Avoid starting esketamine if baseline pressure is uncontrolled.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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