Drug interactions
Esketamine + Phenylephrine po
Severity: Moderate
Esketamine and Phenylephrine po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral phenylephrine is an alpha-adrenergic agonist that may raise blood pressure, and esketamine also elevates blood pressure. The combination can produce additive hypertensive effects, particularly in patients with cardiovascular disease.
What this interaction means in plain words
Esketamine and Phenylephrine po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pressor effects from alpha-1 adrenergic agonism and esketamine sympathetic stimulation.
What to do
Monitor blood pressure before and after esketamine sessions. Suggest avoiding oral decongestants on treatment days in patients with hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Esketamine and Phenylephrine po, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Phenylephrine po?
MediHelp rates the interaction as moderate. Esketamine and Phenylephrine po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral phenylephrine is an alpha-adrenergic agonist that may raise blood pressure, and esketamine also elevates blood pressure. The combination can produce additive hypertensive effects, particularly in patients with cardiovascular disease.
How serious is the interaction between Esketamine and Phenylephrine po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and after esketamine sessions. Suggest avoiding oral decongestants on treatment days in patients with hypertension.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
