Drug interactions
Esketamine + Pimozide
Severity: Moderate
Esketamine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide is an antipsychotic that can cause sedation and significant QT prolongation. Esketamine may add sedation and raise heart rate and blood pressure, so the combination may increase cardiovascular risk in susceptible patients.
What this interaction means in plain words
Esketamine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible added cardiovascular stress alongside the QT effect of pimozide.
What to do
Check baseline ECG and electrolytes, and monitor blood pressure and sedation after esketamine dosing. Avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Esketamine with Pimozide?
MediHelp rates the interaction as moderate. Esketamine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide is an antipsychotic that can cause sedation and significant QT prolongation. Esketamine may add sedation and raise heart rate and blood pressure, so the combination may increase cardiovascular risk in susceptible patients.
How serious is the interaction between Esketamine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and monitor blood pressure and sedation after esketamine dosing. Avoid adding other QT-prolonging drugs.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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