Drug interactions
Esketamine + Quazepam
Severity: Moderate
Esketamine and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine hypnotic that can add to esketamine's sedation, impairing alertness and breathing. Residual effects may extend into the following day.
What this interaction means in plain words
Esketamine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and NMDA antagonism.
What to do
Monitor sedation and respiratory status during the post-dose period and consider skipping the benzodiazepine dose on treatment days. Warn patients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Quazepam?
MediHelp rates the interaction as moderate. Esketamine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a long-acting benzodiazepine hypnotic that can add to esketamine's sedation, impairing alertness and breathing. Residual effects may extend into the following day.
How serious is the interaction between Esketamine and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status during the post-dose period and consider skipping the benzodiazepine dose on treatment days. Warn patients about driving.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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