Drug interactions
Esketamine + Reserpine
Severity: Moderate
Esketamine and Reserpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reserpine depletes monoamine stores and can cause sedation, depression and low blood pressure. Combined with esketamine, drowsiness may increase and blood pressure responses can be unpredictable.
What this interaction means in plain words
Esketamine and Reserpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and altered sympathetic tone from vesicular monoamine depletion combined with NMDA antagonism.
What to do
Monitor sedation and blood pressure before and after esketamine dosing. Review the need for reserpine in patients being treated for depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Reserpine?
MediHelp rates the interaction as moderate. Esketamine and Reserpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Reserpine depletes monoamine stores and can cause sedation, depression and low blood pressure. Combined with esketamine, drowsiness may increase and blood pressure responses can be unpredictable.
How serious is the interaction between Esketamine and Reserpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure before and after esketamine dosing. Review the need for reserpine in patients being treated for depression.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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