Drug interactions
Esketamine + Sufentanil sl
Severity: Major
Esketamine and Sufentanil sl: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual sufentanil is a potent opioid that causes sedation and respiratory depression, and esketamine adds its own sedative effect. Concurrent use can lead to profound sedation and respiratory depression.
What this interaction means in plain words
Esketamine and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system and respiratory depression from the two agents.
What to do
Monitor sedation and oxygen saturation closely, especially after esketamine administration. Limit sufentanil doses and avoid redosing if the patient is excessively sedated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Sufentanil sl?
MediHelp rates the interaction as major. Esketamine and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sublingual sufentanil is a potent opioid that causes sedation and respiratory depression, and esketamine adds its own sedative effect. Concurrent use can lead to profound sedation and respiratory depression.
How serious is the interaction between Esketamine and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation closely, especially after esketamine administration. Limit sufentanil doses and avoid redosing if the patient is excessively sedated.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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