Drug interactions
Esketamine + Thalidomide
Severity: Moderate
Esketamine and Thalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thalidomide frequently causes somnolence and esketamine also sedates, so the combination can increase drowsiness and impair alertness.
What this interaction means in plain words
Esketamine and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Thalidomide belongs to Miscellaneous.
Why it happens
Additive CNS depressant effects of the two agents.
What to do
Monitor for excessive sedation and advise against driving or operating machinery. Give thalidomide at bedtime and separate it from esketamine sessions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Esketamine and Thalidomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Esketamine
Other interactions of Thalidomide
Frequently asked questions
Can I take Esketamine with Thalidomide?
MediHelp rates the interaction as moderate. Esketamine and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thalidomide frequently causes somnolence and esketamine also sedates, so the combination can increase drowsiness and impair alertness.
How serious is the interaction between Esketamine and Thalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and advise against driving or operating machinery. Give thalidomide at bedtime and separate it from esketamine sessions.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
