Drug interactions
Esketamine + Tiagabine
Severity: Moderate
Esketamine and Tiagabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tiagabine commonly causes dizziness and somnolence and esketamine adds sedation and dissociation. The combination may increase drowsiness and impair psychomotor function.
What this interaction means in plain words
Esketamine and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA reuptake inhibition and NMDA antagonism.
What to do
Monitor for excess sedation and cognitive impairment during esketamine treatment. Advise patients not to drive until the day after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Tiagabine?
MediHelp rates the interaction as moderate. Esketamine and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tiagabine commonly causes dizziness and somnolence and esketamine adds sedation and dissociation. The combination may increase drowsiness and impair psychomotor function.
How serious is the interaction between Esketamine and Tiagabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and cognitive impairment during esketamine treatment. Advise patients not to drive until the day after dosing.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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