Drug interactions
Esketamine + Topiramate
Severity: Moderate
Esketamine and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate can cause drowsiness, slowed thinking and dizziness, which may add to esketamine effects. The combination can worsen cognitive and psychomotor impairment.
What this interaction means in plain words
Esketamine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depression via pharmacodynamic synergism.
What to do
Monitor sedation and cognition during esketamine sessions and counsel on avoiding driving afterward.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Topiramate
Frequently asked questions
Can I take Esketamine with Topiramate?
MediHelp rates the interaction as moderate. Esketamine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topiramate can cause drowsiness, slowed thinking and dizziness, which may add to esketamine effects. The combination can worsen cognitive and psychomotor impairment.
How serious is the interaction between Esketamine and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and cognition during esketamine sessions and counsel on avoiding driving afterward.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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