Drug interactions
Esketamine + Triazolam
Severity: Moderate
Esketamine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is a potent short-acting benzodiazepine, and combined with esketamine it can intensify sedation and psychomotor impairment. Respiratory depression is also possible.
What this interaction means in plain words
Esketamine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through NMDA receptor antagonism and GABA-A potentiation.
What to do
Monitor sedation and respiratory status after esketamine administration. Avoid taking triazolam on the morning of an esketamine session and lower the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Triazolam?
MediHelp rates the interaction as moderate. Esketamine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triazolam is a potent short-acting benzodiazepine, and combined with esketamine it can intensify sedation and psychomotor impairment. Respiratory depression is also possible.
How serious is the interaction between Esketamine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status after esketamine administration. Avoid taking triazolam on the morning of an esketamine session and lower the dose if needed.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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