Drug interactions
Esketamine + Triprolidine
Severity: Moderate
Esketamine and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triprolidine is a sedating first-generation antihistamine and can increase drowsiness and psychomotor impairment with esketamine.
What this interaction means in plain words
Esketamine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression from central H1 antagonism plus NMDA antagonism.
What to do
Monitor sedation and avoid driving after dosing; use a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Triprolidine
Frequently asked questions
Can I take Esketamine with Triprolidine?
MediHelp rates the interaction as moderate. Esketamine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triprolidine is a sedating first-generation antihistamine and can increase drowsiness and psychomotor impairment with esketamine.
How serious is the interaction between Esketamine and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and avoid driving after dosing; use a non-sedating antihistamine if one is needed.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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