Drug interactions
Esketamine + Valerian
Severity: Minor
Esketamine and Valerian: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has mild sedative effects and may add to the sedation caused by esketamine. Clinical data are scarce, so the risk is largely theoretical.
What this interaction means in plain words
Esketamine and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive sedation through GABAergic effects of valerian constituents.
What to do
Ask patients about herbal sedative use and monitor for excess drowsiness after esketamine dosing. Advise avoiding valerian on treatment days if sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Frequently asked questions
Can I take Esketamine with Valerian?
MediHelp rates the interaction as minor. Esketamine and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valerian has mild sedative effects and may add to the sedation caused by esketamine. Clinical data are scarce, so the risk is largely theoretical.
How serious is the interaction between Esketamine and Valerian?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal sedative use and monitor for excess drowsiness after esketamine dosing. Advise avoiding valerian on treatment days if sedation is troublesome.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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