Drug interactions
Esketamine + Zaleplon
Severity: Moderate
Esketamine and Zaleplon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zaleplon is a sedative-hypnotic and with esketamine may increase sedation, impaired coordination and complex sleep behaviors.
What this interaction means in plain words
Esketamine and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Zaleplon belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A positive modulation plus NMDA antagonism.
What to do
Avoid taking zaleplon on the day of esketamine treatment when possible and monitor sedation after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Esketamine with Zaleplon?
MediHelp rates the interaction as moderate. Esketamine and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zaleplon is a sedative-hypnotic and with esketamine may increase sedation, impaired coordination and complex sleep behaviors.
How serious is the interaction between Esketamine and Zaleplon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking zaleplon on the day of esketamine treatment when possible and monitor sedation after dosing.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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