Drug interactions
Esketamine intranasal + Ethosuximide
Severity: Moderate
Esketamine intranasal and Ethosuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and ethosuximide also causes drowsiness. Together they may deepen sedation and impair psychomotor function.
What this interaction means in plain words
Esketamine intranasal and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation during esketamine sessions, and observe patients as required by the esketamine program. Counsel against driving until the next day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Frequently asked questions
Can I take Esketamine intranasal with Ethosuximide?
MediHelp rates the interaction as moderate. Esketamine intranasal and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation and dissociation, and ethosuximide also causes drowsiness. Together they may deepen sedation and impair psychomotor function.
How serious is the interaction between Esketamine intranasal and Ethosuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation during esketamine sessions, and observe patients as required by the esketamine program. Counsel against driving until the next day.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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