Drug interactions
Esketamine intranasal + Gabapentin
Severity: Moderate
Esketamine intranasal and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation, dissociation and rarely respiratory depression, and gabapentin adds CNS depression. Combined use may increase oversedation, particularly in the post-dose observation period.
What this interaction means in plain words
Esketamine intranasal and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through pharmacodynamic synergism.
What to do
Monitor sedation and respiratory status during the post-dose observation period. Consider lowering the gabapentin dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gabapentin
Frequently asked questions
Can I take Esketamine intranasal with Gabapentin?
MediHelp rates the interaction as moderate. Esketamine intranasal and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation, dissociation and rarely respiratory depression, and gabapentin adds CNS depression. Combined use may increase oversedation, particularly in the post-dose observation period.
How serious is the interaction between Esketamine intranasal and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status during the post-dose observation period. Consider lowering the gabapentin dose if excessive sedation occurs.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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