Drug interactions
Esketamine intranasal + Lamotrigine
Severity: Moderate
Esketamine intranasal and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation, dissociation and dizziness, and lamotrigine may add to CNS depression. Lamotrigine may also reduce some glutamatergic effects of ketamine-like drugs.
What this interaction means in plain words
Esketamine intranasal and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; lamotrigine may also modulate glutamate release.
What to do
Monitor sedation for at least two hours after each esketamine dose as labeling requires. Counsel the patient not to drive until the next day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Frequently asked questions
Can I take Esketamine intranasal with Lamotrigine?
MediHelp rates the interaction as moderate. Esketamine intranasal and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation, dissociation and dizziness, and lamotrigine may add to CNS depression. Lamotrigine may also reduce some glutamatergic effects of ketamine-like drugs.
How serious is the interaction between Esketamine intranasal and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation for at least two hours after each esketamine dose as labeling requires. Counsel the patient not to drive until the next day.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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