Drug interactions
Esketamine intranasal + Meclizine
Severity: Moderate
Esketamine intranasal and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation, dissociation and dizziness, and meclizine can add to drowsiness. The combination may increase impairment and fall risk after dosing.
What this interaction means in plain words
Esketamine intranasal and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from NMDA antagonism and H1-antihistamine effects.
What to do
Monitor sedation during the post-dose observation period and advise the patient not to drive until the next day after sleep. Avoid giving meclizine around the session if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclizine
Frequently asked questions
Can I take Esketamine intranasal with Meclizine?
MediHelp rates the interaction as moderate. Esketamine intranasal and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation, dissociation and dizziness, and meclizine can add to drowsiness. The combination may increase impairment and fall risk after dosing.
How serious is the interaction between Esketamine intranasal and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation during the post-dose observation period and advise the patient not to drive until the next day after sleep. Avoid giving meclizine around the session if possible.
What other medicines interact with Meclizine?
MediHelp also lists interactions of Meclizine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Meclizine page.
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