Drug interactions
Esketamine intranasal + Olanzapine
Severity: Moderate
Esketamine intranasal and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and olanzapine adds sedative effects. The combination may increase drowsiness and impair alertness after dosing.
What this interaction means in plain words
Esketamine intranasal and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through pharmacodynamic effects.
What to do
Observe patients during and after each esketamine session, as required by the esketamine monitoring program. Counsel patients not to drive until the next day after a restful sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Esketamine intranasal with Olanzapine?
MediHelp rates the interaction as moderate. Esketamine intranasal and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation and dissociation, and olanzapine adds sedative effects. The combination may increase drowsiness and impair alertness after dosing.
How serious is the interaction between Esketamine intranasal and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe patients during and after each esketamine session, as required by the esketamine monitoring program. Counsel patients not to drive until the next day after a restful sleep.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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