Drug interactions
Esketamine intranasal + Pimozide
Severity: Moderate
Esketamine intranasal and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and pimozide adds CNS depression. The combination may increase drowsiness and impair psychomotor function.
What this interaction means in plain words
Esketamine intranasal and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Monitor patients for sedation during the post-dose observation period and avoid driving until the next day. Reduce other sedating drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Esketamine intranasal with Pimozide?
MediHelp rates the interaction as moderate. Esketamine intranasal and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation and dissociation, and pimozide adds CNS depression. The combination may increase drowsiness and impair psychomotor function.
How serious is the interaction between Esketamine intranasal and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients for sedation during the post-dose observation period and avoid driving until the next day. Reduce other sedating drugs where possible.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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